Phenolic Constituents from Fallopia multiflora (Thunberg) Haraldson

Thi Thoa Nguyen,1,2,3 Thanh Binh Pham,2 Nguyen Phuong Thao ,2 Nguyen Hai Dang,1,2 Van Hung Nguyen,2 Van Cuong Pham,2 Chau Van Minh,2 Quang Hai Tran,3 and Nguyen Tien Dat 1,4. Bài báo của nhóm tác giả thuộc trường Đại học Khoa học và công nghệ - Viện Hàn lâm Khoa học và công nghệ Việt Nam; Viện Hóa sinh biển; Trung tâm chuyển giao công nghệ - Viện Hàn lâm Khoa học và công nghệ Việt Nam; Khoa Công nghệ hóa - Trường Đại học Công nghiệp Hà Nội. Bài báo được đăng trên tạp chí Journal of Chemistry, Volume 2018. doi.org/10.1155/2018/4851439

Four naphtolic glycosides (1–4), three anthraquinones (5–7), two stilbenes (8-9), one benzyl glycoside (10), and one flavonoid (11) were isolated from the roots of Fallopia multiflora. )e new compounds were elucidated to be 6-hydroxymusizin 8-O-α-D-apiofuranosyl-
(1→6)-β-D-glucopyranoside (1) and 6-methoxy-3-methyl-1,6,8-trihydroxy-2-naphthoic acid 8-O-β-D-glucopyranoside (3). Compound
3 could be an important marker for chemotaxonomy of F. multiflora. Benzyl gentiobioside (10) was isolated for the first time from the
family Polygonaceae.

1. Introduction
Fallopia multiflora ()unberg) Haraldson (Polygonaceae), synonym Polygonum multiflorum )unb., is an important medicinal plant in riental medicine. It is grown for various medicinal values ranging from bowel relaxation, antiaging, hair loss prevention, increasing sexual vigour, treatment of high cholesterol, high blood pressure, and inflammation [1]. Previous phytochemical investigations have revealed the presence of stilbenes and anthraquinones as major components in F. multiflora [2]. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucopyranoside, emodin, and physcion are used as main markers for quality control of F. multiflora materials and related products [3]. Flavonoids and proanthocyanidins were also found in this plant [3, 4]. Several naphtolic compounds including torachrysone-8-O- β-D-glucopyranoside, torachrysone-8-O-(6′-O-acetyl)-β-Dglucopyranoside, and torachrysone-8-O-(6′-O-galloyl)-β-Dglucoside were also reported [3]. In the present study, a phytochemical investigation of the Fallopia multiflora roots led to the isolation of two new (1 and 3) and nine known compounds (Figure 1).

Toàn văn bài báo: